@import url(https://fonts.googleapis.com/css?family=Roboto+Condensed:300,400,700,900);:root,[data-bs-theme=light]{--bs-blue:#0d6efd;--bs-indigo:#6610f2;--bs-purple:#6f42c1;--bs-pink:#d63384;--bs-red:#dc3545;--bs-orange:#fd7e14;--bs-yellow:#ffc107;--bs-green:#198754;--bs-teal:#20c997;--bs-cyan:#0dcaf0;--bs-black:#000;--bs-white:#fff;--bs-gray:#6c757d;--bs-gray-dark:#343a40;--bs-gray-100:#f8f9fa;--bs-gray-200:#e9ecef;--bs-gray-300:#dee2e6;--bs-gray-400:#ced4da;--bs-gray-500:#adb5bd;--bs-gray-600:#6c757d;--bs-gray-700:#495057;--bs-gray-800:#343a40;--bs-gray-900:#212529;--bs-primary:#0d6efd;--bs-secondary:#6c757d;--bs-success:#198754;--bs-info:#0dcaf0;--bs-warning:#ffc107;--bs-danger:#dc3545;--bs-light:#f8f9fa;--bs-dark:#212529;--bs-primary-rgb:13,110,253;--bs-secondary-rgb:108,117,125;--bs-success-rgb:25,135,84;--bs-info-rgb:13,202,240;--bs-warning-rgb:255,193,7;--bs-danger-rgb:220,53,69;--bs-light-rgb:248,249,250;--bs-dark-rgb:33,37,41;--bs-primary-text-emphasis:#052c65;--bs-secondary-text-emphasis:#2b2f32;--bs-success-text-emphasis:#0a3622;--bs-info-text-emphasis:#055160;--bs-warning-text-emphasis:#664d03;--bs-danger-text-emphasis:#58151c;--bs-light-text-emphasis:#495057;--bs-dark-text-emphasis:#495057;--bs-primary-bg-subtle:#cfe2ff;--bs-secondary-bg-subtle:#e2e3e5;--bs-success-bg-subtle:#d1e7dd;--bs-info-bg-subtle:#cff4fc;--bs-warning-bg-subtle:#fff3cd;--bs-danger-bg-subtle:#f8d7da;--bs-light-bg-subtle:#fcfcfd;--bs-dark-bg-subtle:#ced4da;--bs-primary-border-subtle:#9ec5fe;--bs-secondary-border-subtle:#c4c8cb;--bs-success-border-subtle:#a3cfbb;--bs-info-border-subtle:#9eeaf9;--bs-warning-border-subtle:#ffe69c;--bs-danger-border-subtle:#f1aeb5;--bs-light-border-subtle:#e9ecef;--bs-dark-border-subtle:#adb5bd;--bs-white-rgb:255,255,255;--bs-black-rgb:0,0,0;--bs-font-sans-serif:system-ui,-apple-system,"Segoe UI",Roboto,"Helvetica Neue","Noto Sans","Liberation Sans",Arial,sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";--bs-font-monospace:SFMono-Regular,Menlo,Monaco,Consolas,"Liberation Mono","Courier New",monospace;--bs-gradient:linear-gradient(180deg,hsla(0,0%,100%,.15),hsla(0,0%,100%,0));--bs-body-font-family:var(--bs-font-sans-serif);--bs-body-font-size:1rem;--bs-body-font-weight:400;--bs-body-line-height:1.5;--bs-body-color:#212529;--bs-body-color-rgb:33,37,41;--bs-body-bg:#fff;--bs-body-bg-rgb:255,255,255;--bs-emphasis-color:#000;--bs-emphasis-color-rgb:0,0,0;--bs-secondary-color:rgba(33,37,41,.75);--bs-secondary-color-rgb:33,37,41;--bs-secondary-bg:#e9ecef;--bs-secondary-bg-rgb:233,236,239;--bs-tertiary-color:rgba(33,37,41,.5);--bs-tertiary-color-rgb:33,37,41;--bs-tertiary-bg:#f8f9fa;--bs-tertiary-bg-rgb:248,249,250;--bs-heading-color:inherit;--bs-link-color:#0d6efd;--bs-link-color-rgb:13,110,253;--bs-link-decoration:underline;--bs-link-hover-color:#0a58ca;--bs-link-hover-color-rgb:10,88,202;--bs-code-color:#d63384;--bs-highlight-color:#212529;--bs-highlight-bg:#fff3cd;--bs-border-width:1px;--bs-border-style:solid;--bs-border-color:#dee2e6;--bs-border-color-translucent:rgba(0,0,0,.175);--bs-border-radius:0.375rem;--bs-border-radius-sm:0.25rem;--bs-border-radius-lg:0.5rem;--bs-border-radius-xl:1rem;--bs-border-radius-xxl:2rem;--bs-border-radius-2xl:var(--bs-border-radius-xxl);--bs-border-radius-pill:50rem;--bs-box-shadow:0 0.5rem 1rem rgba(0,0,0,.15);--bs-box-shadow-sm:0 0.125rem 0.25rem rgba(0,0,0,.075);--bs-box-shadow-lg:0 1rem 3rem rgba(0,0,0,.175);--bs-box-shadow-inset:inset 0 1px 2px rgba(0,0,0,.075);--bs-focus-ring-width:0.25rem;--bs-focus-ring-opacity:0.25;--bs-focus-ring-color:rgba(13,110,253,.25);--bs-form-valid-color:#198754;--bs-form-valid-border-color:#198754;--bs-form-invalid-color:#dc3545;--bs-form-invalid-border-color:#dc3545}[data-bs-theme=dark]{--bs-body-color:#dee2e6;--bs-body-color-rgb:222,226,230;--bs-body-bg:#212529;--bs-body-bg-rgb:33,37,41;--bs-emphasis-color:#fff;--bs-emphasis-color-rgb:255,255,255;--bs-secondary-color:rgba(222,226,230,.75);--bs-secondary-color-rgb:222,226,230;--bs-secondary-bg:#343a40;--bs-secondary-bg-rgb:52,58,64;--bs-tertiary-color:rgba(222,226,230,.5);--bs-tertiary-color-rgb:222,226,230;--bs-tertiary-bg:#2b3035;--bs-tertiary-bg-rgb:43,48,53;--bs-primary-text-emphasis:#6ea8fe;--bs-secondary-text-emphasis:#a7acb1;--bs-success-text-emphasis:#75b798;--bs-info-text-emphasis:#6edff6;--bs-warning-text-emphasis:#ffda6a;--bs-danger-text-emphasis:#ea868f;--bs-light-text-emphasis:#f8f9fa;--bs-dark-text-emphasis:#dee2e6;--bs-primary-bg-subtle:#031633;--bs-secondary-bg-subtle:#161719;--bs-success-bg-subtle:#051b11;--bs-info-bg-subtle:#032830;--bs-warning-bg-subtle:#332701;--bs-danger-bg-subtle:#2c0b0e;--bs-light-bg-subtle:#343a40;--bs-dark-bg-subtle:#1a1d20;--bs-primary-border-subtle:#084298;--bs-secondary-border-subtle:#41464b;--bs-success-border-subtle:#0f5132;--bs-info-border-subtle:#087990;--bs-warning-border-subtle:#997404;--bs-danger-border-subtle:#842029;--bs-light-border-subtle:#495057;--bs-dark-border-subtle:#343a40;--bs-heading-color:inherit;--bs-link-color:#6ea8fe;--bs-link-hover-color:#8bb9fe;--bs-link-color-rgb:110,168,254;--bs-link-hover-color-rgb:139,185,254;--bs-code-color:#e685b5;--bs-highlight-color:#dee2e6;--bs-highlight-bg:#664d03;--bs-border-color:#495057;--bs-border-color-translucent:hsla(0,0%,100%,.15);--bs-form-valid-color:#75b798;--bs-form-valid-border-color:#75b798;--bs-form-invalid-color:#ea868f;--bs-form-invalid-border-color:#ea868f;color-scheme:dark}*,:after,:before{box-sizing:border-box}@media (prefers-reduced-motion:no-preference){:root{scroll-behavior:smooth}}body{-webkit-text-size-adjust:100%;-webkit-tap-highlight-color:rgba(0,0,0,0);background-color:var(--bs-body-bg);color:var(--bs-body-color);font-family:var(--bs-body-font-family);font-size:var(--bs-body-font-size);font-weight:var(--bs-body-font-weight);line-height:var(--bs-body-line-height);margin:0;text-align:var(--bs-body-text-align)}hr{border:0;border-top:var(--bs-border-width) solid;color:inherit;margin:1rem 0;opacity:.25}h1,h2,h3,h4,h5,h6{color:var(--bs-heading-color);font-weight:500;line-height:1.2;margin-bottom:.5rem;margin-top:0}h1{font-size:calc(1.375rem + 1.5vw)}@media (min-width:1200px){h1{font-size:2.5rem}}h2{font-size:calc(1.325rem + .9vw)}@media (min-width:1200px){h2{font-size:2rem}}h3{font-size:calc(1.3rem + .6vw)}@media (min-width:1200px){h3{font-size:1.75rem}}h4{font-size:calc(1.275rem + .3vw)}@media (min-width:1200px){h4{font-size:1.5rem}}h5{font-size:1.25rem}h6{font-size:1rem}p{margin-bottom:1rem;margin-top:0}abbr[title]{cursor:help;-webkit-text-decoration:underline dotted;text-decoration:underline dotted;-webkit-text-decoration-skip-ink:none;text-decoration-skip-ink:none}address{font-style:normal;line-height:inherit;margin-bottom:1rem}ol,ul{padding-left:2rem}dl,ol,ul{margin-bottom:1rem;margin-top:0}ol ol,ol ul,ul ol,ul ul{margin-bottom:0}dt{font-weight:700}dd{margin-bottom:.5rem;margin-left:0}blockquote{margin:0 0 1rem}b,strong{font-weight:bolder}small{font-size:.875em}mark{background-color:var(--bs-highlight-bg);color:var(--bs-highlight-color);padding:.1875em}sub,sup{font-size:.75em;line-height:0;position:relative;vertical-align:baseline}sub{bottom:-.25em}sup{top:-.5em}a{color:rgba(var(--bs-link-color-rgb),var(--bs-link-opacity,1));text-decoration:underline}a:hover{--bs-link-color-rgb:var(--bs-link-hover-color-rgb)}a:not([href]):not([class]),a:not([href]):not([class]):hover{color:inherit;text-decoration:none}code,kbd,pre,samp{font-family:var(--bs-font-monospace);font-size:1em}pre{display:block;font-size:.875em;margin-bottom:1rem;margin-top:0;overflow:auto}pre code{color:inherit;font-size:inherit;word-break:normal}code{word-wrap:break-word;color:var(--bs-code-color);font-size:.875em}a>code{color:inherit}kbd{background-color:var(--bs-body-color);border-radius:.25rem;color:var(--bs-body-bg);font-size:.875em;padding:.1875rem .375rem}kbd kbd{font-size:1em;padding:0}figure{margin:0 0 1rem}img,svg{vertical-align:middle}table{border-collapse:collapse;caption-side:bottom}caption{color:var(--bs-secondary-color);padding-bottom:.5rem;padding-top:.5rem;text-align:left}th{text-align:inherit;text-align:-webkit-match-parent}tbody,td,tfoot,th,thead,tr{border:0 solid;border-color:inherit}label{display:inline-block}button{border-radius:0}button:focus:not(:focus-visible){outline:0}button,input,optgroup,select,textarea{font-family:inherit;font-size:inherit;line-height:inherit;margin:0}button,select{text-transform:none}[role=button]{cursor:pointer}select{word-wrap:normal}select:disabled{opacity:1}[list]:not([type=date]):not([type=datetime-local]):not([type=month]):not([type=week]):not([type=time])::-webkit-calendar-picker-indicator{display:none!important}[type=button],[type=reset],[type=submit],button{-webkit-appearance:button}[type=button]:not(:disabled),[type=reset]:not(:disabled),[type=submit]:not(:disabled),button:not(:disabled){cursor:pointer}::-moz-focus-inner{border-style:none;padding:0}textarea{resize:vertical}fieldset{border:0;margin:0;min-width:0;padding:0}legend{float:left;font-size:calc(1.275rem + .3vw);line-height:inherit;margin-bottom:.5rem;padding:0;width:100%}@media (min-width:1200px){legend{font-size:1.5rem}}legend+*{clear:left}::-webkit-datetime-edit-day-field,::-webkit-datetime-edit-fields-wrapper,::-webkit-datetime-edit-hour-field,::-webkit-datetime-edit-minute,::-webkit-datetime-edit-month-field,::-webkit-datetime-edit-text,::-webkit-datetime-edit-year-field{padding:0}::-webkit-inner-spin-button{height:auto}[type=search]{-webkit-appearance:textfield;outline-offset:-2px}::-webkit-search-decoration{-webkit-appearance:none}::-webkit-color-swatch-wrapper{padding:0}::-webkit-file-upload-button{-webkit-appearance:button;font:inherit}::file-selector-button{-webkit-appearance:button;font:inherit}output{display:inline-block}iframe{border:0}summary{cursor:pointer;display:list-item}progress{vertical-align:baseline}[hidden]{display:none!important}:root{--color-key:#62d5d9;--color-key-dark1:#117f93;--color-key-dark2:#0f6272;--color-key-dark3:#125263;--color-black:#444;--color-gray:#94928d;--color-pale-gray:#fff;--color-light-gray:#eaeae9;--color-darker-gray:#dbdbdb;--color-selected:#fd0;--color-selected-hover:rgba(255,221,0,.2);--color-selected-light:#fdfae5;--color-singleton:#fff5b3;--color-suggest:#ffff50;--color-disable:#999;--color-disable-deep:grey;--color-separator:rgba(0,0,0,.3);--color-separator-sub:rgba(0,0,0,.2);--color-mutation-ref:#249eb3;--color-mutation-alt:#ff6682;--color-dataset-gemj:#dc2828;--color-dataset-gemj-light:#fceded;--color-dataset-jga:#62d5d9;--color-dataset-jga-light:#f2fbfc;--color-dataset-tommo:#ca678d;--color-dataset-tommo-light:#fff;--color-dataset-hgvd:#005b80;--color-dataset-hgvd-light:#e6f8ff;--color-dataset-ncbn:#234b7c;--color-dataset-ncbn-light:#fff;--color-dataset-bbj:#ff993f;--color-dataset-bbj-light:#fff8f2;--color-dataset-foreign:#94928d;--color-dataset-foreign-light:#f7f7f6;--color-sign-safe:#04af58;--color-sign-safe-light:#e7fef2;--color-sign-normal:#9dcf3a;--color-sign-normal-light:#f3f9e6;--color-sign-warning:#ffae00;--color-sign-warning-light:#fff7e6;--color-sign-lowdangerous:#ff953c;--color-sign-lowdangerous-light:#ffe3cb;--color-sign-dangerous:#ff5a54;--color-sign-dangerous-light:#ffeeed;--color-sign-modifier:#c654ff;--color-sign-modifier-light:#f9edff;--color-sign-other:#9c8200;--color-sign-other-light:#fff7cf;--color-sign-unknown:#bbba7e;--color-sign-unknown-light:#f9f9f3;--height-inline:18px;--height-advanced-search-condition-values-container:24px;--height-advanced-search-condition-value:18px;--z-index-base:10000;--z-index-layout-aside:calc(var(--z-index-base) + 100);--z-index-row-indicator:calc(var(--z-index-base) + 100);--z-index-advanced-search-menu:calc(var(--z-index-base) + 100);--z-index-detail-header:calc(var(--z-index-base) + 100);--z-index-module-tabs-view:calc(var(--z-index-base) + 200);--z-index-global-header:calc(var(--z-index-base) + 200);--z-index-suggest-view:calc(var(--z-index-base) + 200);--z-index-drawer:calc(var(--z-index-base) + 300);--z-index-configuration:calc(var(--z-index-base) + 400);--z-index-editing-condition:calc(var(--z-index-base) + 400);--z-index-activity-indicator:calc(var(--z-index-base) + 500);--char-TIMES:"ï€";--char-INFO_CIRCLE:"ïš";--char-ARROW_RIGHT:"ï¡";--char-ARROW_DOWN:"ï£";--char-CARET-UP:"";--char-CARET-DOWN:"";--char-EXCRAMATION_TRIANGLE:"ï±";--char-EXTERNAL_LINK:"ï‚Ž";--char-ARROW_CIRCLE_RIGHT:"ï‚©";--char-WRENCH:"ï‚";--char-CHECK:"";--char-dataset:"î €";--char-logical-op-and:"î ";--char-logical-op-or:"î ‚";--char-logical-op-outline:"î ƒ";--char-edit:"î „";--char-delete:"î …";--char-group:"î †";--char-ungroup:"î ‡";--char-copy:"î ˆ"}@font-face{font-family:FontAwesome;src:url(/fonts/fontawesome-webfont-8b43027f47b20503057dfbbaa9401fef.eot);src:url(/fonts/fontawesome-webfont-8b43027f47b20503057dfbbaa9401fef.eot) format("embedded-opentype"),url(/fonts/fontawesome-webfont-20fd1704ea223900efa9fd4e869efb08.woff2) format("woff2"),url(/fonts/fontawesome-webfont-f691f37e57f04c152e2315ab7dbad881.woff) format("woff"),url(/fonts/fontawesome-webfont-1e59d2330b4c6deb84b340635ed36249.ttf) format("truetype"),url(/images/fontawesome-webfont-c1e38fd9e0e74ba58f7a2b77ef29fdd3.svg) format("svg")}@font-face{font-family:fontello;src:url(/fonts/fontello-402050fcb3937047929b8a0c719cc2eb.eot);src:url(/fonts/fontello-402050fcb3937047929b8a0c719cc2eb.eot) format("embedded-opentype"),url(/fonts/fontello-e3cf5a812dc048a47c613c34d59a109e.woff2) format("woff2"),url(/fonts/fontello-fbda13e7bda01e3437485ddcc5680116.woff) format("woff"),url(/fonts/fontello-ad14afcdbca1ceb240b0bdfd2d99bd64.ttf) format("truetype"),url(/images/fontello-ee93feb188a9b0603e096a8e06d933fd.svg) format("svg")}html{height:100%;scroll-behavior:smooth}body{-moz-osx-font-smoothing:grayscale;-webkit-font-smoothing:antialiased;color:#444;font-family:Roboto Condensed,sans-serif;font-size:10px;padding-top:50px!important}[data-page=home] body{overflow:hidden}body[data-search-mode=advanced] #FilterAlphaMissense,body[data-search-mode=advanced] #FilterAlternativeAlleleFrequency,body[data-search-mode=advanced] #FilterPolyPhen,body[data-search-mode=advanced] #FilterSIFT,body[data-search-mode=advanced] #FilterVariantCallingQuality{display:none}body[data-dragging=true]{user-select:none}[draggable=true]{-khtml-user-drag:element}a,a:link{color:#125263}a:link{text-decoration:underline}a:active,a:hover{color:#117f93}label>input{margin-right:.3em}input[type=checkbox],input[type=radio]{vertical-align:middle}input[type=email],input[type=number],input[type=password],input[type=text]{--font-size:12px;border:1px solid var(--color-gray);border-radius:calc(var(--height-inline)*.5);box-shadow:inset 0 1px 1px rgba(0,0,0,.2);display:inline-block;font-size:var(--font-size);line-height:var(--height-inline);outline:none;padding:0 .75em}input[type=number]{padding-right:.25em;text-align:right}select{display:inline-block;height:var(--height-inline);line-height:var(--height-inline)}::part(input-field)::placeholder,::placeholder{color:#94928d;font-family:Roboto Condensed,sans-serif}.unimplemented{color:red;margin-bottom:0}.unimplemented:before{content:"unimplemented: "}.LayoutMainAside{display:flex;height:calc(100% - 30px)}.LayoutMainAside>.LayoutMain{transition:width .2s;width:calc(100% - 300px)}body[data-search-mode=AdvancedSearchView] .LayoutMainAside>.LayoutMain{width:100%}body.-rowselected .LayoutMainAside>.LayoutMain{width:calc(100% - 300px)}.LayoutMainAside>.LayoutAside{background-color:#125263;box-shadow:inset 2px 0 2px rgba(0,0,0,.2);overflow-x:hidden;position:relative;width:300px;z-index:var(--z-index-layout-aside)}body[data-search-mode=AdvancedSearchView] .LayoutMainAside>.LayoutAside{width:0}body.-rowselected .LayoutMainAside>.LayoutAside{width:300px}.LayoutReport{background-color:#eaeae9;padding:18px 18px 18px 25px}.above-headline{margin-bottom:0}.above-headline>dt{font-size:14px;line-height:16px;padding:2px 0}.above-headline>dd{display:flex;flex-wrap:wrap;justify-content:space-between;line-height:16px;margin-bottom:0}.above-headline>dd>.clinical-significance{display:inline-block;vertical-align:middle;white-space:nowrap}.above-headline>dd>.disease-category{align-self:flex-end;display:flex;font-size:12px;font-weight:700;gap:5px;margin-left:auto;margin-right:5px}.above-headline>dd>.disease-category>.mgend{color:#6e5c9e}.above-headline>dd>.disease-category>.clinvar{color:#20558a}.above-headline+.above-headline{border-top:1px solid rgba(0,0,0,.3);margin-top:8px;padding-top:6px}.advanced-search-condition-editor-view{--padding-side:calc(var(--height-advanced-search-condition-values-container)*0.5);border-top:1px solid rgba(0,0,0,.3);color:#444}.advanced-search-condition-editor-view>.sections{border-bottom:1px solid rgba(0,0,0,.3)}.advanced-search-condition-editor-view>.sections>section>header{background-color:#cdcdcc;font-weight:700;padding:0 var(--padding-side)}.advanced-search-condition-editor-view>.sections>section>.body{padding:4px var(--padding-side)}.advanced-search-condition-editor-view>.sections>section>.body[data-type=clinical-significance]{padding-top:2px}.advanced-search-condition-editor-view>.sections>section>.body>.row{display:flex;place-items:center}.advanced-search-condition-editor-view>.sections>section>.body label{margin-bottom:0}.advanced-search-condition-editor-view>.sections>section>.body .container{position:relative}.advanced-search-condition-editor-view>.sections>section>.body .container>.loading{align-items:center;display:flex;height:100%;justify-content:center;left:0;position:absolute;top:0;width:100%;z-index:9}.advanced-search-condition-editor-view>.sections>section>.body .container>.loading>span{background:url(/images/loading-ec0614c8aafb15ea53228fd74fc4ce81.gif) no-repeat 50% 50%;display:block;height:100%;width:100%}.advanced-search-condition-editor-view>.buttons{padding:3px 0 4px;text-align:center}.advanced-search-condition-editor-view>.buttons>.button-view{display:inline-block}.advanced-search-condition-item-view{--padding-values-vertical:calc((var(--height-advanced-search-condition-values-container) - var(--height-advanced-search-condition-value))*0.5);margin-bottom:3px;position:relative}.advanced-search-condition-item-view>.body{background-color:#fff;border-radius:12px;box-shadow:0 1px 1px rgba(0,0,0,.3);position:relative}.advanced-search-condition-item-view>.body>.summary{align-items:stretch;background-color:#f0f0ef;border-radius:12px;color:#444;display:flex;font-size:12px;min-height:24px;padding-right:8px}.advanced-search-condition-item-view>.body>.summary>.classification{background-color:#444;border-bottom-left-radius:12px;border-top-left-radius:12px;color:#fff;cursor:grab;font-weight:700;line-height:24px;min-width:188px;padding:0 0 0 12px;width:188px}.advanced-search-condition-item-view>.body>.summary>.relation{margin:4px -8px;min-width:16px;width:16px}.advanced-search-condition-item-view>.body>.summary>.values{align-items:center;flex-grow:1;flex-wrap:wrap;max-height:100px;overflow:auto;padding:var(--padding-values-vertical) 12px var(--padding-values-vertical) 16px;position:relative}.advanced-search-condition-item-view>.body>.summary>.values::-webkit-scrollbar{-webkit-appearance:none;width:7px}.advanced-search-condition-item-view>.body>.summary>.values::-webkit-scrollbar-thumb{background-color:rgba(0,0,0,.5);border-radius:4px;-webkit-box-shadow:0 0 1px hsla(0,0%,100%,.5)}.advanced-search-condition-item-view>.body>.summary>.buttons{display:flex}.advanced-search-condition-item-view>.body>.summary>.buttons>button{border:none;opacity:.4;padding:0 4px}.advanced-search-condition-item-view>.body>.summary>.buttons>button:hover{opacity:1}.advanced-search-condition-item-view>.body>.summary>.buttons>button:before{font-family:fontello}.advanced-search-condition-item-view>.body>.summary>.buttons>.edit:before{content:var(--char-edit)}.advanced-search-condition-item-view>.body>.summary>.buttons>.delete:before{content:var(--char-delete)}.advanced-search-condition-item-view>.body>.advanced-search-condition-editor-view{background-color:#fff;border-bottom-left-radius:12px;border-bottom-right-radius:12px;border-top:none;display:none;height:0;transition:height .2s}.advanced-search-condition-item-view>.bg{background:radial-gradient(ellipse at center,rgba(98,213,217,.6) 10%,rgba(98,213,217,.8) 60%,#125263 120%);height:100vh;left:0;opacity:0;pointer-events:none;position:fixed;top:0;transition:opacity .5s;width:100vw}.advanced-search-condition-item-view.-editing>.body{z-index:10501}.advanced-search-condition-item-view.-editing>.body>.summary{border-radius:12px 12px 0}.advanced-search-condition-item-view.-editing>.body>.summary>.classification{border-bottom-left-radius:0}.advanced-search-condition-item-view.-editing>.body>.summary>.buttons{opacity:0;pointer-events:none}.advanced-search-condition-item-view.-editing>.body>.summary>.values>condition-item-value-view::part(delete-tag-btn){display:inline-block}.advanced-search-condition-item-view.-editing>.body>.advanced-search-condition-editor-view{display:block;height:auto}.advanced-search-condition-item-view.-editing>.bg{opacity:1;pointer-events:auto;z-index:10500}.advanced-search-condition-item-view[data-relation=eq]>.body>.summary>.relation,.advanced-search-condition-item-view[data-relation=ne]>.body>.summary>.relation{background-color:#117f93;border-radius:3px;cursor:pointer;height:16px;position:relative;z-index:1}.advanced-search-condition-item-view[data-relation=eq]>.body>.summary>.relation:after,.advanced-search-condition-item-view[data-relation=eq]>.body>.summary>.relation:before,.advanced-search-condition-item-view[data-relation=ne]>.body>.summary>.relation:after,.advanced-search-condition-item-view[data-relation=ne]>.body>.summary>.relation:before{content:"";display:block;position:absolute}.advanced-search-condition-item-view[data-relation=eq]>.body>.summary>.relation:before,.advanced-search-condition-item-view[data-relation=ne]>.body>.summary>.relation:before{background-color:#fff;box-shadow:0 4px #fff;height:2px;left:4px;top:5px;width:8px}.advanced-search-condition-item-view[data-relation=ne]>.body>.summary>.classification{background-color:gray}.advanced-search-condition-item-view[data-relation=ne]>.body>.summary>.relation{background-color:#999}.advanced-search-condition-item-view[data-relation=ne]>.body>.summary>.relation:after{border-left:1px solid #fff;height:12px;left:6.5px;top:2px;transform:rotate(-20deg)}.advanced-search-condition-item-view.-selected:after{border:2px solid #fd0;border-radius:12px;content:"";display:block;height:100%;left:0;pointer-events:none;position:absolute;top:0;width:100%}.advanced-search-condition-item-view[data-classification=significance]>.body>.summary>.values>.mgend-wrapper{display:flex}.advanced-search-condition-item-view[data-classification=significance]>.body>.summary>.values>.mgend-wrapper>span{font-weight:700;min-width:45px}.advanced-search-condition-item-view[data-classification=significance]>.body>.summary>.values>.mgend-wrapper>span.mgend{color:#6e5c9e}.advanced-search-condition-item-view[data-classification=significance]>.body>.summary>.values>.clinvar-wrapper{display:flex}.advanced-search-condition-item-view[data-classification=significance]>.body>.summary>.values>.clinvar-wrapper>span{font-weight:700;min-width:45px}.advanced-search-condition-item-view[data-classification=significance]>.body>.summary>.values>.clinvar-wrapper>span.clinvar{color:#20558a}.advanced-search-condition-group-view{background-color:#fff;border:1px solid #125263;box-shadow:0 1px 1px rgba(0,0,0,.3);margin:0 calc(var(--padding-group)*-1 - 1px) 3px 0;position:relative}.advanced-search-condition-group-view>.logical-operator-switch{left:20px;position:absolute;top:5px;transform:rotate(90deg);transform-origin:0 0}.advanced-search-condition-group-view>.container{padding:var(--padding-group) var(--padding-group) calc(var(--padding-group) - 2px) 22px}.advanced-search-condition-group-view[data-number-of-child="0"]>.logical-operator-switch,.advanced-search-condition-group-view[data-number-of-child="1"]>.logical-operator-switch{visibility:hidden}.advanced-search-condition-group-view.-selected:after{border:2px solid #fd0;content:"";display:block;height:100%;left:0;pointer-events:none;position:absolute;top:0;width:100%}.advanced-search-condition-group-view.-root{padding-bottom:calc(var(--height-toolbar) + 1px)}.advanced-search-condition-group-view.-root[data-number-of-child="0"]:before{color:#444;content:"Please add a search condition from below menu";display:block;height:18px;line-height:12px;position:relative;text-align:center;top:10px}.advanced-search-toolbar{background-color:#125263;color:#fff;font-size:12px;line-height:14px;margin:0 0 calc(var(--height-toolbar)*-1 - 1px) 0;padding:2px 6px}.advanced-search-toolbar>ul{display:flex;list-style:none;margin:0;padding-left:0;white-space:nowrap}.advanced-search-toolbar>ul>li>p{cursor:pointer;margin-bottom:0;padding:4px 8px 3px;transition:background-color .2s}.advanced-search-toolbar>ul>li .shortcut{background-color:#fff;border-radius:2px;color:#125263;display:none;font-size:10px;font-weight:700;height:12px;line-height:12px;margin-left:4px;padding:0 3px}[data-os=mac] .advanced-search-toolbar>ul>li .shortcut>.char.-command:before{content:"⌘"}[data-os=windows] .advanced-search-toolbar>ul>li .shortcut>.char.-command:before{content:"ctrl ";font-weight:400}.advanced-search-toolbar>ul>li:hover>p{background-color:#117f93}.advanced-search-toolbar>ul>li.-haschild{position:relative}body[data-dragging=true] .advanced-search-toolbar>ul>li.-haschild{pointer-events:none}.advanced-search-toolbar>ul>li.-haschild>p:after{border-color:#fff transparent transparent;border-style:solid;border-width:4px 3px 0;content:"";display:inline-block;margin-left:4px;vertical-align:middle}.advanced-search-toolbar>ul>li.-haschild>ul{background-color:#125263;list-style:none;opacity:0;padding:0 0 2px;pointer-events:none;position:absolute;transform:translateY(-10px);transition:opacity .2s,transform .2s;white-space:nowrap;z-index:10100}.advanced-search-toolbar>ul>li.-haschild>ul>li{align-items:center;cursor:pointer;display:flex;transition:background-color .2s}.advanced-search-toolbar>ul>li.-haschild>ul>li>p{flex-grow:1;margin-bottom:0;padding-right:8px}.advanced-search-toolbar>ul>li.-haschild>ul>li:hover{background-color:#117f93}.advanced-search-toolbar>ul>li.-haschild:hover>ul{opacity:1;pointer-events:auto;transform:translateY(0)}.advanced-search-toolbar>ul>li.-haschild:hover>ul>li{padding:4px 8px}.advanced-search-toolbar>ul>li.command{opacity:.5;pointer-events:none}#AdvancedSearchBuilderView[data-can-copy=true] .advanced-search-toolbar>ul>li.command[data-command=copy],#AdvancedSearchBuilderView[data-can-delete=true] .advanced-search-toolbar>ul>li.command[data-command=delete],#AdvancedSearchBuilderView[data-can-group=true] .advanced-search-toolbar>ul>li.command[data-command=group],#AdvancedSearchBuilderView[data-can-ungroup=true] .advanced-search-toolbar>ul>li.command[data-command=ungroup],.advanced-search-toolbar>ul>li.command.-enabled{opacity:1;pointer-events:auto}.advanced-search-toolbar>ul>li.buttoncontainer{flex-grow:1;text-align:right}.advanced-search-toolbar>ul>li.buttoncontainer>.button-view{position:relative;top:1px}.button-view{background:linear-gradient(to bottom,var(--color-key),var(--color-key-dark1));border:none;border-radius:.8em;box-shadow:0 1px 2px rgba(0,0,0,.3);color:#fff;cursor:pointer;font-weight:700;line-height:1.6;padding:0 .8em;position:relative}.button-view.-weak{background:linear-gradient(to bottom,var(--color-pale-gray),var(--color-light-gray));color:var(--color-black)}.button-view.-negative{background:linear-gradient(to bottom,var(--color-disable),var(--color-disable-deep))}.button-view.-disabled{opacity:.4;pointer-events:none}.button-view:hover{box-shadow:0 0 1px rgba(0,0,0,.8);transform:translateY(.5px)}.checklist-values{margin-bottom:0;margin-left:-10px;margin-right:-10px;padding-inline-start:0}.checklist-values:after{clear:both;content:"";display:block}.checklist-values li{clear:both;list-style-type:none;position:relative}.checklist-values>.item{align-items:center;display:flex;justify-content:space-between;padding:2px 10px}.checklist-values>.item>.label{align-items:center;display:flex;font-weight:700;gap:.3rem;line-height:14px;margin-bottom:0}.checklist-values>.item>.label>.clinical-significance,.checklist-values>.item>.label>.dataset-icon,.checklist-values>.item>.label>.variant-function,.checklist-values>.item>.label>.variant-icon{display:inline-block;margin-left:-3px;vertical-align:middle}#FilterDatasets .checklist-values>.item>.label>.dataset-icon{width:56px}#FilterDatasets .checklist-values>.item>.label>.dataset-icon:before{width:15px}body[data-search-mode=advanced] .checklist-values>.item>.label>input[type=checkbox]{display:none}.checklist-values>.item>.value{display:block;float:right;line-height:18px;padding-left:1em}.checklist-values>.item.collapse-view{display:block}.checklist-values>.item.collapse-view>.collapsebutton{left:3px;top:7px}.checklist-values>.separator{height:0;line-height:0;padding:2px 0}.checklist-values>.separator>hr{border:none;border-top:1px solid rgba(0,0,0,.2);margin:0}.checklist-values>.separator+.item{margin-top:4px}.checkboxes-editor-view>.buttons{border-bottom:1px dotted rgba(0,0,0,.2);padding:4px var(--padding-side)}.checkboxes-editor-view>.checkboxes{font-size:14px;line-height:24px;margin:0}.checkboxes-editor-view>.checkboxes>li{display:inline-block;line-height:18px;margin-right:12px}.checkboxes-editor-view>.checkboxes>li:last-child{margin-right:0}.checkboxes-editor-view>.checkboxes>li>label{font-weight:700;margin-bottom:0}.chromosome-position>.chromosome,.chromosome-position>.coordinate{display:inline}.chromosome-position>.chromosome{font-weight:700}.chromosome-position>.chromosome:after{content:": "}.chromosome-view{height:100%;position:relative;text-align:left;transition:width .2s;width:36px}.chromosome-view>.upper{height:18px}.chromosome-view>.upper>.no{background-color:rgba(0,0,0,.25);border-radius:9px;cursor:pointer;display:inline-block;font-size:12px;font-weight:700;height:18px;left:9px;line-height:18px;position:relative;text-align:center;transition:left .2s;width:18px}.chromosome-view>.lower{position:relative}.chromosome-view>.lower>.displayregion,.chromosome-view>.lower>.filteredregion,.chromosome-view>.lower>.selectedregion{left:0;opacity:0;position:absolute;transition:opacity .2s,height .2s,top .2s,left .2s;width:36px}.chromosome-view>.lower>.displayregion.-shown,.chromosome-view>.lower>.filteredregion.-shown,.chromosome-view>.lower>.selectedregion.-shown{opacity:1}.chromosome-view>.lower>.filteredregion{background-color:rgba(255,221,0,.4)}.chromosome-view>.lower>.displayregion{border:1px solid #fd0;border-radius:2px;left:4px;width:28px}.chromosome-view>.lower>.chromosome{display:block;filter:drop-shadow(0 4px 4px rgba(0,0,0,.5));left:12px;position:relative;transition:width .2s,left .2s;width:12px}.chromosome-view>.lower>.chromosome>.subband{cursor:pointer}[data-is-selecting-chromosome=true] .chromosome-view>.lower>.chromosome>.subband{opacity:.3}.chromosome-view>.lower>.chromosome>.subband.-selected{opacity:1}.chromosome-view>.lower>.chromosome>.subband>.subbandrect{fill:url(#chromosome-gneg);transition:fill .2s}.chromosome-view>.lower>.chromosome>.subband>.subbandrect.acen{fill:url(#chromosome-acen)}.chromosome-view>.lower>.chromosome>.subband>.subbandrect.gpos25{fill:url(#chromosome-gpos25)}.chromosome-view>.lower>.chromosome>.subband>.subbandrect.gpos50{fill:url(#chromosome-gpos50)}.chromosome-view>.lower>.chromosome>.subband>.subbandrect.gpos75{fill:url(#chromosome-gpos75)}.chromosome-view>.lower>.chromosome>.subband>.subbandrect.gpos100,.chromosome-view>.lower>.chromosome>.subband>.subbandrect.gvar{fill:url(#chromosome-gpos100)}.chromosome-view>.lower>.chromosome>.subband>.subbandrect.stalk{fill:url(#chromosome-stalk)}.chromosome-view>.lower>.chromosome>.subband.-hover,.chromosome-view>.lower>.chromosome>.subband:hover{opacity:1}.chromosome-view>.lower>.chromosome>.subband.-hover>.subbandrect,.chromosome-view>.lower>.chromosome>.subband:hover>.subbandrect{fill:#fd0}.chromosome-view>.lower>.chromosome>.band{cursor:pointer}[data-is-selecting-chromosome=true] .chromosome-view>.lower>.chromosome>.band{opacity:.3}.chromosome-view>.lower>.chromosome>.band.-selected,.chromosome-view>.lower>.chromosome>.band:hover{opacity:1}.chromosome-view>.lower>.chromosome>.band>.bandtext{fill:#fff;font-size:12px;line-height:12px}.chromosome-view>.lower>.chromosome>.band>.line{stroke:#fff;stroke-width:.5px;fill:transparent}.chromosome-view>.lower>.chromosome>.band:hover>.bandtext{fill:#fd0}.chromosome-view>.lower>.chromosome>.band:hover>.line{stroke:#fd0}.chromosome-view>.lower>.selectedregion{background-color:rgba(255,221,0,.15);border-radius:1px}.-show-band-label .chromosome-view{width:68px}.-show-band-label .chromosome-view>.upper>.no{left:25px}.-show-band-label .chromosome-view>.lower>.displayregion,.-show-band-label .chromosome-view>.lower>.filteredregion,.-show-band-label .chromosome-view>.lower>.selectedregion{left:16px}.-show-band-label .chromosome-view>.lower>.displayregion{left:20px}.-show-band-label .chromosome-view>.lower>.chromosome{left:28px;width:44px}.clinical-significance{color:#125263}.clinical-significance:before{border:1px solid transparent;border-radius:9px;display:inline-block;font-size:10px;font-weight:700;height:18px;line-height:18px;margin-right:3px;text-align:center;vertical-align:top;width:18px}.clinical-significance[data-value=PLP]:before,.clinical-significance[data-value=P]:before{content:"P"}.clinical-significance[data-value=LPLP]:before,.clinical-significance[data-value=LP]:before{content:"LP"}.clinical-significance[data-value=LP]:before,.clinical-significance[data-value=P]:before{background-color:#ffeeed;border-color:#ff5a54;color:#ff5a54}.clinical-significance[data-value=LPLP]:before,.clinical-significance[data-value=PLP]:before{background-color:#ffe3cb;border-color:#ff953c;color:#ff953c}.clinical-significance[data-value=ERA]:before,.clinical-significance[data-value=LRA]:before,.clinical-significance[data-value=URA]:before{background-color:#fff7e6;border-color:#ffae00;color:#ffae00;content:"RA"}.clinical-significance[data-value=US]:before{background-color:#f9f9f3;border-color:#bbba7e;color:#bbba7e;content:"US"}.clinical-significance[data-value=LB]:before{background-color:#f3f9e6;border-color:#9dcf3a;color:#9dcf3a;content:"LB"}.clinical-significance[data-value=B]:before{background-color:#e7fef2;border-color:#04af58;color:#04af58;content:"B"}.clinical-significance[data-value=CI]:before{background-color:#f9edff;border-color:#c654ff;color:#c654ff;content:"CI"}.clinical-significance[data-value=DR]:before{content:"DR"}.clinical-significance[data-value=CS]:before{content:"CS"}.clinical-significance[data-value=RF]:before{content:"RF"}.clinical-significance[data-value=A]:before{content:"A"}.clinical-significance[data-value=PR]:before{content:"PR"}.clinical-significance[data-value=AF]:before{content:"AF"}.clinical-significance[data-value=AF]:before,.clinical-significance[data-value=A]:before,.clinical-significance[data-value=CS]:before,.clinical-significance[data-value=DR]:before,.clinical-significance[data-value=PR]:before,.clinical-significance[data-value=RF]:before{background-color:#fff7cf;border-color:#9c8200;color:#9c8200}.clinical-significance[data-value=O]:before{content:"O"}.clinical-significance[data-value=NP]:before{content:"NP"}.clinical-significance[data-value=AN]:before{content:"AN"}.clinical-significance[data-value=AN]:before,.clinical-significance[data-value=NP]:before,.clinical-significance[data-value=O]:before{background-color:#fff;border-color:#94928d;color:#94928d}.collapse-view{position:relative}.collapse-view>.collapsebutton{cursor:pointer;position:absolute;transition:top .2s}.collapse-view>.collapsebutton:before{border:.1rem solid #fff;border-bottom:none;border-right:none;content:"";display:block;height:7px;transform:rotate(45deg);transform-origin:25% 50%;transition:transform .2s;width:7px}.collapse-view.-collapsed>.collapsebutton:before{transform:rotate(225deg)}.collapse-view.-collapsed>.collapsecontent{display:none}.collapse-view.-hierarchic>.collapsebutton:before{border-bottom:4px solid transparent;border-left:5px solid #444;border-top:4px solid transparent;transform:rotate(90deg)}.collapse-view.-hierarchic>.collapsecontent{padding-left:1rem}.collapse-view.-hierarchic.-collapsed>.collapsebutton:before{transform:rotate(0deg)}.collapse-view.-hierarchic.-unstructured[data-collapse-depth="1"]{margin-left:12px}.collapse-view.-hierarchic.-unstructured[data-collapse-depth="2"]{margin-left:24px}.collapse-view.-hierarchic.-unstructured[data-collapse-depth="3"]{margin-left:36px}.columns-editor-view>.body{display:flex;overflow:auto;padding:0!important}.columns-editor-view>.body>.columns{display:flex}.columns-editor-view>.body>.columns>.column{border-right:1px solid rgba(0,0,0,.3);max-height:200px;overflow-y:auto;padding:4px 0}.columns-editor-view>.body>.columns>.column>ul{margin:0;padding:0}.columns-editor-view>.body>.columns>.column>ul>li{font-size:14px;line-height:24px;list-style:none;padding-left:12px;padding-right:18px;position:relative;white-space:nowrap}.columns-editor-view>.body>.columns>.column>ul>li>.arrow{border-color:transparent transparent transparent #444;border-style:solid;border-width:4px 0 4px 6px;cursor:pointer;display:block;height:0;opacity:.2;position:absolute;right:6px;top:7px;transition:opacity .2s;width:0}.columns-editor-view>.body>.columns>.column>ul>li.-selected>.arrow,.columns-editor-view>.body>.columns>.column>ul>li>.arrow:hover{opacity:1}.columns-editor-view>.body>.columns>.column>ul>li>label{margin-bottom:0}.columns-editor-view>.body>.columns>.column>ul>li>label>input{vertical-align:middle}.columns-editor-view>.body>.columns>.column>ul>li>label>span{font-weight:700}.common-document>.header{background:linear-gradient(90deg,#117f93,#62d5d9);color:#fff;min-width:864px;padding:27px 0 10px}.common-document>.header>.title{font-size:21px;line-height:27px;margin:0 auto;padding-left:18px;padding-right:18px;width:864px}.common-document>.contents{font-size:14px;line-height:1.8;margin:0 auto;padding:24px 18px 36px;width:864px}.common-document>.contents+.contents{margin-top:-36px}.common-document>.contents>.section{padding:24px 0}.common-document>.contents>.section:last-child{padding-bottom:60px;position:relative}.common-document>.contents>.section:last-child:after{background-color:#117f93;bottom:0;content:"";display:block;height:2px;left:-4px;position:absolute;width:calc(100% + 8px)}.common-document>.contents>.section>.sectiontitle{color:#125263;font-size:18px;position:relative}.common-document>.contents>.section>.sectiontitle:after,.common-document>.contents>.section>.sectiontitle:before{content:"";display:block;position:absolute}.common-document>.contents>.section>.sectiontitle#diseases_jgad000123{scroll-margin-top:50px}.common-document>.contents>.section .table{font-size:14px;line-height:1.2;width:100%}.common-document>.contents>.section .table td,.common-document>.contents>.section .table th{padding:4px;vertical-align:top}.common-document>.contents>.section .table>thead>tr{border-bottom:1px solid #444}.common-document>.contents>.section .table>tbody>tr{border-bottom:1px solid rgba(68,68,68,.4)}.common-document>.contents>.section .table>tfoot>tr{border-top:1px solid #444}.common-document>.contents>.section .notice{font-size:12px;line-height:1.4;margin-top:8px}.common-document>.contents>.section .unordered-list{list-style:none;padding-inline-start:0}.common-document>.contents>.section .unordered-list>li{line-height:1.6;padding:4px 0 4px 1em;position:relative}.common-document>.contents>.section .unordered-list>li:before{background-color:#62d5d9;border-radius:100%;content:"";display:inline-block;height:5px;left:-7px;position:relative;top:-3px;width:5px}.common-document>.contents>.section .ordered-list{counter-reset:item;list-style:none;padding-inline-start:0}.common-document>.contents>.section .ordered-list>li{padding:4px 0 4px 2em;position:relative}.common-document>.contents>.section .ordered-list>li:before{background-color:#62d5d9;border-radius:9px;color:#fff;content:counters(item,".") " ";counter-increment:item;display:block;font-weight:700;height:18px;line-height:18px;padding:0 6px;position:absolute;right:calc(100% - 21px);text-align:center;top:7px}.common-document>.contents>.section .ordered-list>li+li{margin-top:1em}.common-document>.contents>.section .ordered-list>li>.heading{color:#117f93;font-size:14px;line-height:1.6}.common-document>.contents>.section .ordered-list>li .subsection{line-height:1.4;padding-top:.5em}.common-document>.contents>.section .ordered-list>li .subsection>.subheading{color:#444;font-size:12px;line-height:1.2}.common-document>.contents>.section .variant-function{line-height:18px}.common-document>.contents>.section img{max-width:100%}.common-document>.contents.-two-columns>.section{column-count:2;column-gap:4em;column-rule:1px solid rgba(98,213,217,.6);hyphens:auto;orphans:2;text-align:justify;widows:2;word-break:break-all}.common-document>.contents.-two-columns>.section>.sectiontitle{column-span:all}.common-document>.contents.-two-columns>.section .subsection{break-inside:avoid}.common-document .results-view>tbody>tr:hover{background-color:transparent}.clinical-significance-view>.buttons{border-bottom:1px dotted rgba(0,0,0,.2);padding:4px var(--padding-side)}.clinical-significance-view>.dataset-title{font-size:14px;font-weight:700;padding-left:var(--padding-side);padding-top:2px}.clinical-significance-view>.dataset-title.clinvar{color:#20558a}.clinical-significance-view>.dataset-title.mgend{color:#6e5c9e}.clinical-significance-view>hr{border:1px dotted rgba(0,0,0,.2);margin:0}.clinical-significance-view>.checkboxes{display:grid;font-size:14px;grid-template-columns:1fr 1fr 1fr;margin:0;row-gap:3px}.clinical-significance-view>.checkboxes>li{display:inline-block;line-height:18px;margin-right:5px}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=LP]{grid-area:2/1}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=PLP]{grid-area:3/1}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=LPLP]{grid-area:4/1}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=ERA]{grid-area:5/1}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=LRA]{grid-area:6/1}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=URA]{grid-area:7/1}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=US]{grid-area:1/2}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=LB]{grid-area:2/2}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=B]{grid-area:3/2}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=CI]{grid-area:4/2}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=DR]{grid-area:5/2}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=CS]{grid-area:6/2}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=RF]{grid-area:7/2}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=A]{grid-area:1/3}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=PR]{grid-area:2/3}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=AF]{grid-area:3/3}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=O]{grid-area:4/3}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=NP]{grid-area:5/3}.clinical-significance-view>.checkboxes>li[data-source=clinvar][data-value=AN]{grid-area:6/3}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=PLP]{grid-area:1/1}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=LP]{grid-area:2/1}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=US]{grid-area:3/1}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=LB]{grid-area:1/2}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=B]{grid-area:2/2}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=DR]{grid-area:3/2}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=O]{grid-area:1/3}.clinical-significance-view>.checkboxes>li[data-source=mgend][data-value=NP]{grid-area:2/3}.clinical-significance-view>.checkboxes>li>label{font-weight:700}#ConditionDiseaseSearch>.container{margin-top:.5rem}.pathogenicity-editor-view[data-condition-type=pathogenicity_prediction] .body{padding:0 0 75px!important}.pathogenicity-editor-view[data-condition-type=pathogenicity_prediction] ul[role=tablist]{background:#e2e2e2;display:flex;font-size:12px;font-weight:700;gap:.1rem;list-style:none;margin:0;padding:0 0 0 10px}.pathogenicity-editor-view[data-condition-type=pathogenicity_prediction] ul[role=tablist] li a{border-radius:7px 7px 0 0;color:#444;display:block;margin-top:5px;outline:none;padding:3px 8px;text-decoration:none}.pathogenicity-editor-view[data-condition-type=pathogenicity_prediction] ul[role=tablist] li a[aria-selected=true]{background-color:#fff}.pathogenicity-editor-view[data-condition-type=pathogenicity_prediction] .tabs-panels{padding:10px}.variant-icon{background-image:url(/images/csssprite-cf1adb219c835832dba41e976f466b97.png);background-position:0 0;background-repeat:no-repeat;background-size:200px 60px;height:26px;width:32px}.variant-icon.-snv{background-position:0 -20px}.variant-icon.-insertion{background-position:-40px -20px}.variant-icon.-deletion{background-position:-80px -20px}.variant-icon.-indel{background-position:-120px -20px}.variant-icon.-substitution{background-position:-160px -20px}.dataset-icon{font-family:fontello;height:18px;position:relative}.dataset-icon:before{content:"î €";display:inline-block;height:18px;left:2px;margin-right:2px;position:relative}.dataset-icon>.properties{display:inline-flex;flex-direction:column;font-family:Roboto Condensed;font-size:10px;font-weight:lighter;height:20px;justify-content:center;left:-2px;line-height:9px;position:relative;top:-1px;transform:scale(.9);vertical-align:middle}.dataset-icon>.properties:after,.dataset-icon>.properties:before{display:block;height:10px}.dataset-icon[data-dataset=jga_snp]:before,.dataset-icon[data-dataset=jga_wes]:before,.dataset-icon[data-dataset=jga_wgs]:before{color:#62d5d9}.dataset-icon[data-dataset=tommo]:before{color:#ca678d}.dataset-icon[data-dataset=hgvd]:before,.dataset-icon[data-dataset=mgend]:before{color:#005b80}.dataset-icon[data-dataset=ncbn]:before{color:#234b7c}.dataset-icon[data-dataset=gem_j_wga]:before{color:#dc2828}.dataset-icon[data-dataset=bbj]:before{color:#ff993f}.dataset-icon[data-dataset=gnomad_exomes]:before,.dataset-icon[data-dataset=gnomad_genomes]:before{color:#94928d}.dataset-icon[data-dataset=clinvar]:before,.dataset-icon[data-dataset=mgend]:before{color:#ff5a54;content:"ï§";font-family:FontAwesome;font-size:14px}.dataset-icon[data-dataset=clinvar]>.properties:before,.dataset-icon[data-dataset=mgend]>.properties:before{color:#ff5a54;content:"Disease"}.dataset-icon[data-dataset=gem_j_wga]>.properties:after,.dataset-icon[data-dataset=gnomad_genomes]>.properties:after,.dataset-icon[data-dataset=ncbn]>.properties:after,.dataset-icon[data-dataset=tommo]>.properties:after{content:"WGS"}.dataset-icon[data-dataset=gnomad_exomes]>.properties:after,.dataset-icon[data-dataset=hgvd]>.properties:after,.dataset-icon[data-dataset=jga_wes]>.properties:after,.dataset-icon[data-dataset=jga_wgs]>.properties:after{content:"WES"}.dataset-icon[data-dataset=bbj]>.properties:after,.dataset-icon[data-dataset=jga_snp]>.properties:after{content:"SNP"}.drawer-view{background-color:#444;bottom:-370px;color:#fff;position:fixed;transition:bottom .5s;width:100%;z-index:10300}.-drawer-opened .drawer-view{bottom:0}.drawer-view>.header{border-bottom:1px solid rgba(0,0,0,.2);border-top:1px solid hsla(0,0%,100%,.4);cursor:pointer;height:30px;line-height:30px;padding:0 16px}.drawer-view>.header>.mark{border-left:1px solid #fff;border-top:1px solid #fff;display:inline-block;height:7px;margin-right:.7em;margin-top:-.8em;position:relative;transform:rotate(45deg);transform:rotate(225deg);transition:transform .2s,top .2s;vertical-align:middle;width:7px}.-drawer-opened .drawer-view>.header>.mark{margin-top:-.3em;transform:rotate(45deg)}.drawer-view>.header>.heading{display:inline-block}.drawer-view>.configuration{font-size:12px;max-width:calc(100vw - 120px);opacity:0;overflow-x:auto;pointer-events:none;position:absolute;right:16px;text-align:right;top:5px;transition:opacity .5s;white-space:nowrap}.-drawer-opened .drawer-view>.configuration{opacity:1;pointer-events:auto}.drawer-view>.configuration>.form-parts{display:inline-block}.drawer-view>.configuration>.form-parts+.form-parts{margin-left:.75em}.drawer-view>.configuration>.form-parts>.togglebuttons{background-color:rgba(0,0,0,.5)}.drawer-view>.configuration>.form-parts>.togglebuttons>.button:hover{color:#62d5d9}.drawer-view>.configuration>.form-parts>.select{background-color:rgba(0,0,0,.5);color:#fff}.drawer-view>.content{overflow:hidden;position:relative}.drawer-view>.content>.chromosomes{box-sizing:content-box;height:344px;overflow-x:auto;padding:10px 18px 16px;text-align:center;white-space:nowrap}.drawer-view>.content>.chromosomes>.chromosome-view{display:inline-block;vertical-align:top}.dropdown-view{pasition:relative;font-size:14px}.dropdown-view>.button{background:linear-gradient(to bottom,var(--color-key-dark1),var(--color-key-dark3));border:none;border-radius:10px;color:#fff;cursor:pointer;line-height:20px;margin:0}.dropdown-view>.button:after{content:var(--char-CARET-DOWN);font-family:FontAwesome}.dropdown-view>.selectshow{cursor:pointer;transition:.3s}.dropdown-view>.selectshow:hover{background-color:hsla(0,0%,100%,.1)}.dropdown-view>.selectshow:hover>.list{opacity:1;pointer-events:auto;transform:translateY(0)}.dropdown-view>.selectshow>.list{background-color:#fff;box-shadow:0 2px 2px rgba(0,0,0,.8);cursor:pointer;font-weight:400;list-style:none;margin:0;opacity:0;pointer-events:none;position:relative;top:20px;transform:translateY(-3px);transition:.3s;white-space:nowrap}.dropdown-view>.selectshow>.list>.item>.link{display:block;padding-right:5px;text-decoration:none;transition:.3s}.dropdown-view>.selectshow>.list>.item>.link:before{color:var(--color-key-dark2);content:var(--char-CHECK);font-family:FontAwesome;font-size:.6rem;opacity:0}.dropdown-view>.selectshow>.list>.item>.link:hover{background-color:var(--color-selected-hover)}.dropdown-view>.selectshow>.list>.item>.-active:before{opacity:1}.form-parts>*{display:inline-block}.form-parts>.label{margin-right:.5em}.form-parts>.togglebuttons{background-color:#eaeae9;border-radius:10px;display:inline-block;height:20px;line-height:1;margin-left:-2px;padding:1px}.form-parts>.togglebuttons>.button{border-radius:9px;color:#94928d;cursor:pointer;display:inline-block;font-weight:700;line-height:18px;padding:0 10px;transition:background-color .2s,color .2s,border .2s,box-shadow .2s,line-height .2s}.form-parts>.togglebuttons>.button:hover{color:#125263}.form-parts>.togglebuttons>.button.-current{background-color:#fff;border:1px solid #62d5d9;box-shadow:0 1px 2px rgba(0,0,0,.2);color:#117f93;line-height:16px}.form-parts>.select{border:none;height:18px;line-height:1}.form-parts>.input{border:none;border-radius:10px;box-shadow:inset 0 1px 1px rgba(0,0,0,.3);height:18px;line-height:1;padding:0 8px}.frequency-count-editor-view>.body>section+section{margin-top:5px}.frequency-count-editor-view>.body>section.switching>label{margin-bottom:4px}.frequency-count-editor-view>.body>section.switching>label>span{font-weight:700}.frequency-count-editor-view>.body>section.switching>.input{opacity:.4;pointer-events:none}.frequency-count-editor-view>.body>section.switching.-current>.input{opacity:1;pointer-events:auto}.frequency-count-editor-view>.body>section.frequency>.range-selector-view>.input>label{left:368px;position:absolute}.frequency-count-editor-view>.body>section.count>.input>input{border:1px solid #94928d;border-radius:9px;box-shadow:inset 0 1px 1px rgba(0,0,0,.2);display:inline-block;line-height:18px;margin-right:3px;outline:none;padding:0 0 0 8px;text-align:right;width:5em}.frequency-detail{width:100%}.frequency-detail>tbody>tr>td{line-height:18px}.frequency-detail>tbody>tr>td:first-child{font-weight:700}.frequency-detail>tbody>tr>td .dataset-icon{display:inline-block;margin-right:.2em;vertical-align:middle}.frequency-detail>tbody>tr>td .dataset-icon>.properties{width:inherit}.frequency-detail>tbody>tr>td.alt,.frequency-detail>tbody>tr>td.frequency,.frequency-detail>tbody>tr>td.total{text-align:right}.frequency-detail>tbody>tr>td.alt{color:#ff6682;font-weight:700}.frequency-detail>tbody>tr>td.alt:after{color:#444;content:"/";font-size:10px;margin-left:.5em}.frequency-detail>tbody>tr>td.frequency{font-weight:700}.hyper-text:not([href=""]):after{color:#adaba7;display:inline-block;font-family:FontAwesome;margin-left:.25em}.hyper-text:hover:after{color:#62d5d9}.hyper-text.-internal:not([href=""]):after{content:"ï‚©";font-size:.8em}.hyper-text.-external:not([href=""]):after{content:"ï‚Ž";font-size:.7em}.location-editor-view>.body>.row{line-height:var(--height-inline)}.location-editor-view>.body>.row .label{font-weight:700}.logical-operator-switch{border-radius:.75em;color:#125263;cursor:pointer;line-height:1;padding:.1em .3em}.logical-operator-switch[data-operator=and]:before,.logical-operator-switch[data-operator=or]:before{display:inline-block;font-family:fontello;font-size:1.4em;letter-spacing:-1em;vertical-align:middle;width:1.15em}.logical-operator-switch[data-operator=and]:after,.logical-operator-switch[data-operator=or]:after{bottom:-.1em;font-weight:700;position:relative}.logical-operator-switch[data-operator=and]:before{content:"î ƒî "}.logical-operator-switch[data-operator=and]:after{content:"AND"}.logical-operator-switch[data-operator=or]:before{content:"î ƒî ‚"}.logical-operator-switch[data-operator=or]:after{content:"OR"}.logical-operator-switch:hover{background-color:#125263;color:#fff}.menu-button{border-radius:10px;display:inline-block;height:20px;line-height:20px;padding:0 8px}.menu-button.-current{border:1px solid #117f93;color:#117f93}.menu-button:hover{color:#117f93}.module-tabs-view{background-color:#0f6272;color:#fff}.module-tabs-view>.tabscontainer>ul{margin:0;padding:4px 18px 0}.module-tabs-view>.tabscontainer>ul>li{border-radius:3px 3px 0 0;cursor:pointer;display:inline-block;font-size:14px;font-weight:700;line-height:24px;opacity:.7;padding:2px 12px 0;position:relative;transition:background-color .2s,opacity .2s;z-index:10200}.module-tabs-view>.tabscontainer>ul>li.-current,.module-tabs-view>.tabscontainer>ul>li:hover{background-color:#117f93;opacity:1}.module-tabs-view>.sectionscontainer{background-color:#117f93}.module-tabs-view>.sectionscontainer>.section{position:absolute;visibility:hidden}.module-tabs-view>.sectionscontainer>.section.-current{position:inherit;visibility:inherit}.module-tabs-view.-depth1{background-color:#117f93}.module-tabs-view.-depth1>.sectionscontainer,.module-tabs-view.-depth1>.tabscontainer>ul>li.-current,.module-tabs-view.-depth1>.tabscontainer>ul>li:hover{background-color:#62d5d9}.module-tabs-view.collapse-view{position:relative}.module-tabs-view.collapse-view>.collapsebutton{left:5px;top:16px}.module-tabs-view.collapse-view.-collapsed .collapsebutton{top:13px}.panel-view{background-color:#fff;border-radius:5px;box-shadow:0 2px 2px rgba(0,0,0,.3);font-size:12px;position:relative}.panel-view>.title{border-bottom:1px solid rgba(0,0,0,.3);font-size:14px;line-height:16px;margin-bottom:0;padding:8px 10px 6px}.panel-view>.title:after{border-left:1px solid #444;border-top:1px solid #444;content:"";display:block;height:7px;position:absolute;right:12px;top:13px;transform:rotate(45deg);transition:transform .2s,top .2s;width:7px}.panel-view>.close{cursor:pointer;height:16px;position:absolute;right:7px;top:8px;width:16px}.panel-view>.content{padding:6px 10px 10px}.panel-view+.panel-view{margin-top:5px}.panel-view label{margin-bottom:0}.panel-view.-cannotcollapse>.title{cursor:inherit}.panel-view.-cannotcollapse>.title:after{display:none}.panel-view.-notfound:after{color:#94928d;content:"Not found";display:block;margin:-8px 0 0;padding-bottom:10px;text-align:center}.panel-view.-collapsed>.title{border-bottom:none}.panel-view.-collapsed>.title:after{top:10px;transform:rotate(225deg)}.panel-view.-collapsed>.content{display:none}.panel-view.-collapsed.-notfound:after{content:"";display:none}.panel-view.-emphasize{background:linear-gradient(90deg,#117f93,#62d5d9);transition:background-color .2s}.panel-view.-emphasize.-disable{background:linear-gradient(90deg,grey,#999);color:#fff}.panel-view.-emphasize:hover{background-color:#117f93}.panel-view.-emphasize>.title span,.panel-view.-emphasize>.title>a{color:#fff;display:block;margin:-8px -10px -6px;padding:8px 10px 6px;text-decoration:none}.panel-view.-emphasize>.title span.hyper-text:after,.panel-view.-emphasize>.title>a.hyper-text:after{color:#fff}.frequency-detail>thead>tr>th,.panel-view-heading,.right-headline>tbody>tr>th{color:#94928d;font-size:10px}.page-index{background-color:rgba(98,213,217,.1);border:1px solid #62d5d9;column-count:2;column-gap:4em;list-style:none;margin:0;padding:12px 18px}.page-index>.category{break-inside:avoid}.page-index>.category+.category{margin-top:12px}.page-index>.category>.categorytitle{font-size:16px;line-height:20px;margin-bottom:0;padding:4px 0}.page-index>.category>.categorylist{list-style:none;padding-inline-start:0}.page-index>.category>.categorylist>.item{font-size:14px;line-height:18px;overflow:hidden;padding:4px 0;position:relative}.page-index>.category>.categorylist>.item>.link{color:#444;text-decoration:none}.page-index>.category>.categorylist>.item>.link:hover{color:#62d5d9}.page-index>.category>.categorylist>.item>.link:after{content:"ï£";display:inline-block;font-family:FontAwesome;font-size:10px;opacity:.8;position:relative;top:0;vertical-align:middle}.page-index>.category>.categorylist>.item.-question{padding-left:20px}.page-index>.category>.categorylist>.item.-question>.link:before{background-color:#117f93;border-radius:8px;color:#fff;content:"Q";display:block;font-size:12px;font-weight:700;height:16px;left:0;line-height:16px;position:absolute;text-align:center;top:5px;width:16px}.question-answer{margin-bottom:1em;margin-top:-58px;padding-top:58px}.question-answer>.answer,.question-answer>.question{font-size:14px;padding-left:27px;position:relative}.question-answer>.answer:before,.question-answer>.question:before{border-radius:100%;display:block;font-size:14px;font-weight:700;height:20px;left:0;line-height:20px;position:absolute;text-align:center;width:20px}.question-answer>.question{line-height:18px;padding:4px 0 0 27px}.question-answer>.question:before{background-color:#117f93;color:#fff;content:"Q";top:3px}.question-answer>.answer:before{border:1px solid #117f93;color:#117f93;content:"A";top:2px}.question-answer>.answer>div,.question-answer>.answer>ol,.question-answer>.answer>p,.question-answer>.answer>table,.question-answer>.answer>ul{margin-bottom:1em}.range-inputs-view{display:flex;place-items:center}.range-inputs-view>.line{display:inline-block;height:1px;margin:0 .5em;position:relative;width:.4em}.range-inputs-view>.line:before{border-top:1px solid #000;content:"";display:block;position:relative;top:1px;width:100%}.range-inputs-view[data-type=single_position]>.line{opacity:.2}.range-inputs-view[data-type=single_position]>input.end{opacity:.2;pointer-events:none}range-slider::part(wrapper){column-gap:2em;display:flex;flex-wrap:wrap;row-gap:1em}range-slider::part(label){margin:0}range-slider::part(meter){height:1.5em;margin-top:.5em;max-width:250px;padding:0 8px;position:relative;width:100%;z-index:1}range-slider::part(div-input){text-align:center}range-slider::part(checkbox){vertical-align:middle}range-slider::part(num-input){border:1px solid #94928d;border-radius:9px;box-shadow:inset 0 1px 1px rgba(0,0,0,.2);display:inline-block;font-size:inherit;line-height:18px;margin-right:3px;outline:none;padding:0 0 0 8px;text-align:right;width:5em}range-slider::part(checkbox-label){margin-bottom:0;margin-left:8px}range-slider::part(ruler){font-size:.8em;position:relative}range-slider::part(scale){line-height:1;position:absolute;transform:translateY(13px);z-index:10}range-slider::part(scale):before{border-left:1px dotted rgba(0,0,0,.3);content:"";display:block;height:14px;left:.5em;position:absolute;top:-16px}range-slider::part(meter-container){align-items:center;display:flex;flex-direction:column;position:relative}range-slider::part(slider-track){height:8px;width:calc(100% - 3px)}range-slider::part(slider){-webkit-appearance:none;appearance:none;background-color:transparent;line-height:1em;margin:auto;pointer-events:none;position:absolute;width:100%}range-slider::part(match){text-align-margin-left:1em;text-align:center}range-slider::part(scale-vertical){transform:rotate(90deg) translateX(-2em)}range-slider::part(scale-vertical):before{transform:rotate(90deg) translate(15px,-2em)}.ref-alt{display:flex;font-weight:700}.ref-alt>.alt,.ref-alt>.ref{display:inline-block;height:18px;line-height:18px;padding:0 6px;vertical-align:middle}.ref-alt>.alt[data-sum]:after,.ref-alt>.ref[data-sum]:after{border-radius:6px;color:#fff;content:attr(data-sum) "bp";display:inline-block;font-size:10px;font-weight:lighter;line-height:12px;margin:0 -3px 4px 3px;padding:0 4px;position:relative;vertical-align:middle}.ref-alt>.alt[data-sum="0"]:after,.ref-alt>.alt[data-sum="1"]:after,.ref-alt>.alt[data-sum="2"]:after,.ref-alt>.alt[data-sum="3"]:after,.ref-alt>.alt[data-sum="4"]:after,.ref-alt>.ref[data-sum="0"]:after,.ref-alt>.ref[data-sum="1"]:after,.ref-alt>.ref[data-sum="2"]:after,.ref-alt>.ref[data-sum="3"]:after,.ref-alt>.ref[data-sum="4"]:after{display:none}.ref-alt>.ref{background-color:#d8f0f4;border-bottom:1px solid #249eb3;border-bottom-left-radius:3px;border-left:1px solid #249eb3;border-top:1px solid #249eb3;border-top-left-radius:3px;color:#249eb3;padding-right:4px;position:relative}.ref-alt>.ref[data-sum]:after{background-color:#249eb3}.ref-alt>.alt{background-color:#fde2e7;border-bottom:1px solid #ff6682;border-bottom-right-radius:3px;border-right:1px solid #ff6682;border-top:1px solid #ff6682;border-top-right-radius:3px;color:#ff6682;padding-left:9px}.ref-alt>.alt[data-sum]:after{background-color:#ff6682}.ref-alt>.arrow{position:relative}.ref-alt>.arrow:after,.ref-alt>.arrow:before{content:"";display:inline-block;position:absolute}.ref-alt>.arrow:before{border-bottom:9px solid transparent;border-left:6px solid #249eb3;border-top:9px solid transparent;right:-6px;top:0}.ref-alt>.arrow:after{border-bottom:8px solid transparent;border-left:6px solid #d8f0f4;border-top:8px solid transparent;right:-5px;top:1px}.remains-count{background-color:#eaeae9;border:1px solid #94928d;border-radius:7px;display:inline-block;font-size:10px;line-height:14px;margin-left:4px;padding:0 4px;vertical-align:middle}.remains-count:before{content:"+"}.results-view{border-right:18px solid #fff;font-size:14px;line-height:18px;white-space:nowrap;width:100%}.results-view>thead>tr{border-bottom:2px solid #444;height:36px}.results-view>thead>tr>th{position:relative}.results-view>thead>tr>th>p{bottom:-17px;font-size:12px;left:9px;position:absolute;transform:rotate(-20deg);transform-origin:0 100%}.results-view>thead>tr>th.separator{border-bottom:2px solid #fff}.results-view>thead>tr>th.separator:before{content:"";display:block;width:28px}.results-view>thead>tr.groupingrow{border-bottom:none;height:4px}.results-view>thead>tr.groupingrow>th>p{border-left:1px solid rgba(68,68,68,.5);bottom:-51px;font-weight:400;left:0;line-height:1;padding-bottom:15px;padding-left:5px}.results-view>tbody>tr{border-bottom:1px solid rgba(0,0,0,.3);height:27px;transition:background .2s}.results-view>tbody>tr>td{min-width:2em;padding:2px 10px 2px 6px;transition:background .2s}.results-view>tbody>tr>td[data-remains]:after{background-color:#eaeae9;border:1px solid #94928d;border-radius:7px;content:"+" attr(data-remains);display:inline-block;font-size:10px;line-height:14px;margin-left:4px;padding:0 4px;vertical-align:middle}.results-view>tbody>tr>td[data-remains=""]:after,.results-view>tbody>tr>td[data-remains="0"]:after{display:none}.results-view>tbody>tr>td.separator{border-bottom:1px solid #fff;color:#62d5d9;position:relative}.results-view>tbody>tr>td.separator:before{border-left:1px solid rgba(68,68,68,.5);content:"";display:block;height:11px;left:18px;position:absolute;top:50%;transform:rotate(-20deg) translateY(-6px)}.results-view>tbody>tr>td>.icon[data-remains]:before{background-color:#eaeae9;border:1px solid #94928d;border-radius:7px;content:"+" attr(data-remains);display:inline-block;font-size:10px;line-height:14px;margin-left:4px;padding:0 4px;vertical-align:middle}.results-view>tbody>tr>td>.icon[data-remains=""]:before,.results-view>tbody>tr>td>.icon[data-remains="0"]:before{display:none}.results-view>tbody>tr>td>.icon[data-mgend=true]:after{background:url(/images/mgend-logo-9d27690c5fb1279bdaad248856536805.png) no-repeat;background-size:contain;content:"";display:inline-block;height:16px;margin-left:6px;position:relative;top:3px;width:16px}.results-view>tbody>tr>td>.clinical-significance,.results-view>tbody>tr>td>.consequence-item,.results-view>tbody>tr>td>.dataset-icon,.results-view>tbody>tr>td>.variant-function{display:inline-block;vertical-align:middle}.results-view>tbody>tr>td:last-child{padding-right:6px}.results-view>tbody>tr>td>logarithmized-block-graph-frequency-view{margin-right:-2px}.results-view>tbody>tr:hover{background-color:rgba(255,221,0,.2)}.results-view>tbody>tr.-selected{background-color:rgba(255,221,0,.4)}.results-view>tbody>tr.-loading>td{background:url(/images/loading-ec0614c8aafb15ea53228fd74fc4ce81.gif) no-repeat 50% 50%,rgba(0,0,0,.05);background-size:30px 10px}.results-view>tbody>tr.-out-of-range{display:none}.right-headline>tbody>tr>td,.right-headline>tbody>tr>th{line-height:14px;padding-bottom:2px;padding-top:2px;vertical-align:top}.right-headline>tbody>tr>th{padding-right:.5em;text-align:right}.right-headline>tbody>tr>th:after{content:":"}.right-headline>tbody>tr:first-child>td,.right-headline>tbody>tr:first-child>th{padding-top:6px}.right-headline>tbody>tr:last-child>td,.right-headline>tbody>tr:last-child>th{padding-bottom:6px}.right-headline>tbody>tr>td>ul{margin-bottom:0;padding-block-start:0;padding-inline-start:0}.right-headline>tbody>tr>td>ul>li{display:block;word-break:break-all}.right-headline>tbody+tbody{border-top:1px solid rgba(0,0,0,.2)}.row-indicator{height:27px;opacity:0;overflow:hidden;position:absolute;right:-14px;transform:translateY(77px);transition:opacity .2s,top .2s;width:14px;z-index:10100}.row-indicator:after,.row-indicator:before{content:"";display:block;position:absolute}.row-indicator:before{border-left:9px solid #000;filter:blur(1px);opacity:.4;top:6px}.row-indicator:after,.row-indicator:before{border-bottom:8px solid transparent;border-top:8px solid transparent}.row-indicator:after{border-left:9px solid #fff199;top:5px}.row-indicator.-shown{opacity:1}.scroll-bar{height:calc(100% - 96px);position:absolute;right:0;top:77px;width:16px}.scroll-bar>.bar{background-color:hsla(43,3%,57%,.5);border-radius:4px;cursor:grab;height:100px;left:5px;opacity:1;position:absolute;transition:background-color .2s;width:8px}.scroll-bar>.bar>.indicator{background-color:#117f93;border-radius:9px;color:#fff;font-size:12px;line-height:18px;opacity:0;padding:0 10px;pointer-events:none;position:absolute;right:13px;top:calc(50% - 9px);transition:opacity .5s;white-space:nowrap}.scroll-bar>.bar>.indicator:after{border-bottom:4px solid transparent;border-left:9px solid #117f93;border-top:4px solid transparent;content:"";display:block;position:absolute;right:-7px;top:5px}.scroll-bar>.bar>.indicator>.position{font-weight:700}.scroll-bar>.bar>.indicator>.total{opacity:.75}.scroll-bar>.bar>.indicator>.total:before{content:"/ "}.scroll-bar>.bar.-disabled{display:none}.scroll-bar>.bar.ui-draggable-dragging{background-color:rgba(17,127,147,.5);cursor:grabbing}.scroll-bar:hover>.bar{background-color:rgba(17,127,147,.5)}.scroll-bar.-dragging>.bar>.indicator,.scroll-bar:hover>.bar>.indicator{opacity:1}.search-field-view{padding:10px;position:relative}.search-field-view>.fieldcontainer>.field{margin-bottom:4px}.search-field-view>.fieldcontainer>.field>input[type=text]{border:1px solid #0f6272;border-radius:15px;font-size:12px;height:30px;line-height:30px;opacity:.9;outline:none;padding:0 12px;vertical-align:top;width:100%}.search-field-view>.fieldcontainer>.field>input[type=text]:focus{opacity:1}.search-field-view>.fieldcontainer>.field>button{background-color:#fff;border:1px solid #117f93;border-radius:100%;box-shadow:0 1px 1px rgba(0,0,0,.2);height:30px;margin-right:-4px;position:relative;text-indent:-9999px;width:30px}.search-field-view>.fieldcontainer>.field>button:after,.search-field-view>.fieldcontainer>.field>button:before{content:"";display:block;position:absolute}.search-field-view>.fieldcontainer>.field>button:before{border:2px solid #117f93;border-radius:6px;height:12px;left:6px;top:6px;width:12px}.search-field-view>.fieldcontainer>.field>button:after{border-left:2px solid #117f93;height:5px;left:17px;top:16px;transform:rotate(-45deg)}.search-field-view>.examples>dl{border-radius:8px;cursor:pointer;display:inline-block;font-size:12px;line-height:16px;margin-bottom:0;padding:0 .5em;transition:background-color .2s,box-shadow .2s}.search-field-view>.examples>dl>dd,.search-field-view>.examples>dl>dt{color:#fff;display:inline-block;margin-bottom:0;transition:color .2s}.search-field-view>.examples>dl>dt{font-weight:400;opacity:.6}.search-field-view>.examples>dl>dt:after{content:":"}.search-field-view>.examples>dl:hover{background-color:#0f6272}.search-field-view>.suggest-view{position:absolute}.selection-area{background-color:rgba(255,221,0,.2);border:1px solid #fd0;border-radius:2px}.stanza-view{scroll-margin-top:120px}.stanza-view>.titlelink-wrapper{margin-bottom:4px;margin-left:-15px}.stanza-view>.titlelink-wrapper>.titlelink{color:var(--color-gray);display:inline-block;font-family:FontAwesome;font-size:.7rem;margin-right:3px;text-decoration:none;vertical-align:bottom;width:11px}.stanza-view>.titlelink-wrapper:hover .titlelink:before{content:"ïƒ"}.stanza-view>.titlelink-wrapper>.title{display:inline-block;font-size:16px;line-height:18px;margin:0}.stanza-view>.titlelink-wrapper>.title>span{font-size:12px;margin-left:8px}.stanza-view>.titlelink-wrapper>.title>span.mgend{color:#6e5c9e}.stanza-view>.titlelink-wrapper>.title>span.clinvar{color:#20558a}.stanza-view>.stanza{background:#fff;box-shadow:0 2px 2px rgba(0,0,0,.2);margin-bottom:20px;overflow:scroll}.stanza-view>.stanza togostanza-gene-protein-structure{--togostanza-iframe-max-width:""}.suggest-view{background-color:#fff;box-shadow:0 2px 6px rgba(0,0,0,.2);color:#444;display:flex;font-size:14px;z-index:10200}.suggest-view>.column+.column{border-left:1px solid rgba(0,0,0,.2)}.suggest-view>.column>.title{color:#117f93;font-size:12px;font-weight:400;line-height:16px;margin:4px 0 0;padding:5px 14px 0}.suggest-view>.column>.title:first-letter{text-transform:capitalize}.suggest-view>.column>.empty{color:#94928d;padding:0 14px}.suggest-view>.column>.empty,.suggest-view>.column>.loading{align-items:center;display:flex;height:5rem;justify-content:center;width:20rem}.suggest-view>.column>.loading>span{background:url(/images/loading-ec0614c8aafb15ea53228fd74fc4ce81.gif) no-repeat 50% 50%;display:block;height:100%;width:100%}.suggest-view>.column>.error{align-items:center;color:#94928d;display:flex;height:5rem;justify-content:center;padding:0 14px;width:20rem}.suggest-view>.column>.list{list-style:none;margin:10px 0;overflow-y:auto;padding-left:0}.suggest-view>.column>.list>.item{cursor:pointer;line-height:26px;padding:0 14px;transition:background-color .2s}.suggest-view>.column>.list>.item>em{background-color:var(--color-suggest);font-style:normal}.suggest-view>.column>.list>.item:first-child{height:30px;padding-top:4px}.suggest-view>.column>.list>.item:hover{background-color:rgba(255,221,0,.2)}.suggest-view>.column>.list>.item.-disabled{cursor:auto}.suggest-view>.column>.list>.item.-disabled:hover{background-color:inherit}.suggest-view>.column>.list>.item>.sub{color:rgba(68,68,68,.5);font-size:12px;padding-left:.5em}.suggest-view>.column>.list>.item.-selected{background-color:#fd0}.suggest-view>.column>.list .loading{align-items:center;display:flex;height:100%;justify-content:center;left:0;position:absolute;top:0;width:100%}.suggest-view>.column>.list .loading>span{background:url(/images/loading-ec0614c8aafb15ea53228fd74fc4ce81.gif) no-repeat 50% 50%;display:block;height:100%;width:100%}.tippy-box[data-theme~=black]{background-color:#444;border:1px solid #fff;border-radius:7px;color:#fff;margin:0;padding:.4rem .6rem;white-space:none}.tippy-box .content{margin:0}.tippy-box .content .url{color:#fff;font-weight:bolder;padding-left:.2rem;text-decoration:underline}.tippy-box[data-animation=fade][data-state=hidden]{opacity:0}.tippy-box .tippy-arrow{color:#444;height:2px;width:5px}.tippy-box .tippy-arrow:before{border-color:transparent;border-style:solid;content:"";position:absolute}.tippy-box[data-placement^=top] .tippy-arrow{bottom:0}.tippy-box[data-placement^=top] .tippy-arrow:before{border-left:9px solid transparent;border-right:9px solid transparent;border-top:9px solid #444;bottom:-9px;transform-origin:center top}.tippy-box[data-placement^=bottom] .tippy-arrow{top:0}.tippy-box[data-placement^=bottom] .tippy-arrow:before{border-bottom:9px solid #444;border-left:9px solid transparent;border-right:9px solid transparent;top:-9px;transform-origin:center bottom}.tippy-box[data-placement^=left] .tippy-arrow{right:0}.tippy-box[data-placement^=left] .tippy-arrow:before{border-bottom:9px solid transparent;border-left:9px solid #444;border-top:9px solid transparent;right:-9px;transform-origin:center left}.tippy-box[data-placement^=right] .tippy-arrow{left:0}.tippy-box[data-placement^=right] .tippy-arrow:before{border-bottom:9px solid transparent;border-right:9px solid #444;border-top:9px solid transparent;left:-9px;transform-origin:center right}.languageswitcher{display:flex}.languageswitcher:before{border-right:1px solid #0f6272;content:"";left:25px;position:relative;width:1px}.languageswitcher.en a.en{background-color:rgba(17,127,147,.3);border:1px solid #0f6272;border-right:none;color:#0f6272}.languageswitcher.en a.ja{border:1px solid #94928d;border-left:none;color:#94928d}.languageswitcher.ja a.ja{background-color:rgba(17,127,147,.3);border:1px solid #0f6272;border-left:none;color:#0f6272}.languageswitcher.ja a.en{border:1px solid #94928d;border-right:none;color:#94928d}.languageswitcher a{font-size:12px;line-height:1.5;text-align:center;text-decoration:none;width:24px}.languageswitcher a.en{border-radius:20px 0 0 20px;border-right:1px solid #0f6272}.languageswitcher a.ja{border-radius:0 20px 20px 0}.unexpected-value-string.-null,.unexpected-value-string.-undefined{color:rgba(68,68,68,.5);font-style:oblique}.variant-function{border-radius:9px;color:#fff;display:inline-block;padding:0 8px}.variant-function[data-function=B],.variant-function[data-function=T]{background-color:#04af58}.variant-function[data-function=LB]{background-color:#9dcf3a}.variant-function[data-function=LP],.variant-function[data-function=POSSD]{background-color:#ffae00}.variant-function[data-function=D],.variant-function[data-function=PROBD]{background-color:#ff5a54}.variant-function[data-function=U]{background-color:#eaeae9;color:#444}.variant-function[data-function=A]{background-color:#bbba7e}.variant-type{font-weight:700}#ActivityIndicator{background:url(/images/loading-ec0614c8aafb15ea53228fd74fc4ce81.gif) no-repeat 50% 50% rgba(0,0,0,.05);height:100%;left:0;pointer-events:none;position:fixed;top:0;transition:opacity .5s;width:100%;z-index:10400}#ActivityIndicator.-hidden{opacity:0;pointer-events:none}#AdvancedSearchBuilderView{--padding-group:6px;--height-toolbar:14px;padding:14px;user-select:none}#AdvancedSearchBuilderView>.inner .advanced-search-condition-group-view+.advanced-search-condition-item-view,#AdvancedSearchBuilderView>.inner .advanced-search-condition-item-view+.advanced-search-condition-group-view{margin-top:5px}#AdvancedSearchView .search-field-view{padding:14px}#AdvancedSearchView .search-field-view>.fieldcontainer>.field{margin:0}#AdvancedSearchView .search-field-view>.fieldcontainer>.field>button{display:none}#AdvancedSearchView.-current .search-field-view>.suggest-view{left:25px;top:44px}#Configuration{opacity:0;pointer-events:none;position:fixed;transition:opacity .5s;z-index:10500}#Configuration,#Configuration>.bg{height:100%;left:0;top:0;width:100%}#Configuration>.bg{background:radial-gradient(ellipse at center,rgba(98,213,217,.6) 10%,rgba(98,213,217,.8) 60%,#125263 120%);position:absolute;transition:background .5s}#Configuration>.plate{background-color:#fff;border-radius:5px;left:50%;max-height:calc(100% - 50px);overflow-y:auto;position:absolute;top:50%;transform:translate(-50%,-50%);width:800px}#Configuration>.plate>.header{border-bottom:.5px solid rgba(0,0,0,.3);margin-bottom:0;padding:12px 14px 8px}#Configuration>.plate>.container{padding:8px 14px 27px}#Configuration>.plate>.container>table{font-size:12px;line-height:16px;width:100%}#Configuration>.plate>.container>table>tbody>tr>td,#Configuration>.plate>.container>table>tbody>tr>th{padding:4px 0}#Configuration>.plate>.container>table>tbody>tr>th{padding-right:1em;text-align:right;vertical-align:top;white-space:nowrap}#Configuration>.plate>.container>table>tbody>tr>th:after{content:":"}#Configuration>.plate>.container>table>tbody>tr>td>.group{list-style-type:none;margin-block-end:0;margin-block-start:0;margin-bottom:0;padding-inline-start:0}#Configuration>.plate>.container>table>tbody>tr>td>.group>li{display:inline-block;margin-bottom:2px;margin-right:1em}#Configuration>.plate>.container>table>tbody>tr>td>.group>li>label{margin-bottom:0}#Configuration.-shown{opacity:1;pointer-events:auto}#Configuration.-shown>.bg{background:radial-gradient(ellipse at center,rgba(98,213,217,.3) 10%,rgba(98,213,217,.7) 60%,rgba(18,82,99,.9) 120%)}#DetailHeader{background:linear-gradient(90deg,rgba(17,127,147,.9),rgba(98,213,217,.9));padding:10px 14px 10px 25px;position:sticky;top:50px;z-index:10100}#DetailHeader .title-wrapper{display:inline-block;padding-right:20px;vertical-align:bottom}#DetailHeader .title-wrapper>.pagetype{color:#1f5065;font-size:14px;font-weight:700;line-height:16px;margin-bottom:0}#DetailHeader .title-wrapper>.title{color:#fff;font-size:28px;font-weight:700;line-height:28px;margin-bottom:0}#GlobalHeader{background-color:#fff;box-shadow:0 2px 2px rgba(0,0,0,.2);display:flex;height:50px;justify-content:space-between;position:fixed;top:0;width:100%;z-index:10200}#GlobalHeader>.left{display:flex;padding:10px 14px;position:relative;top:-2px}#GlobalHeader>.left>h1.heading .link{text-decoration:none}#GlobalHeader>.left>h1.heading .link .logotype{display:block;height:31px;left:-5px;margin-right:.3rem;position:relative;width:101px}#GlobalHeader>.left span.summary{font-size:12px;font-weight:400;padding-top:8px}#GlobalHeader>.left nav.dropdown-view{padding-left:8px;padding-top:6px}#GlobalHeader>.left nav.dropdown-view>button.button{padding:0 .7em}#GlobalHeader>.left nav.dropdown-view>button.button:after{font-size:.7rem;left:5px;padding-right:2px;position:relative}#GlobalHeader>.left nav.dropdown-view>.selectshow{height:20px;position:relative;top:-20px}#GlobalHeader>.left nav.dropdown-view>.selectshow>ul.list{padding:3px 0}#GlobalHeader>.left nav.dropdown-view>.selectshow>ul.list>li.item>a.link:before{left:-4px;padding-left:10px;position:relative;top:-1px}#GlobalHeader>.right{align-self:center;font-size:14px;position:relative}#GlobalHeader>.right nav.menus-view>.menu-wrapper{display:flex}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu{display:flex;margin:0;padding:14px 8px}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu>li.menu-button{color:#444}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu>li.menu-button.config{cursor:pointer}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu>li.menu-button.login>a.link{color:#444;min-width:30px;text-decoration:none}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu>li.menu-button.login>a.link:hover,#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu>li.menu-button:hover{color:#117f93}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu>li.menu-button>a.link{display:block;width:100%}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu+.menu{border-left:1px solid rgba(0,0,0,.3)}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu.navigation>.item>a.link{color:#444;text-decoration:none}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu.navigation>.item>a.link:hover{color:#117f93;text-decoration:none}#GlobalHeader>.right nav.menus-view>.menu-wrapper>.menu.navigation>.item.-current>.link{color:#117f93}@media(max-width:1170px){#GlobalHeader>.right{position:relative}#GlobalHeader>.right>.menu-bar:before{content:"";display:inline-block;font-family:FontAwesome;font-size:16px;padding-right:15px}#GlobalHeader>.right>nav.menus-view{display:block;position:absolute;right:15px;top:15px}#GlobalHeader>.right>nav.menus-view>.menu-wrapper{background-color:#fff;box-shadow:0 1px 2px rgba(0,0,0,.8);display:none;flex-direction:column;gap:0;position:relative;top:5px;width:150px}#GlobalHeader>.right>nav.menus-view>.menu-wrapper ul.menu{flex-direction:column;padding:10px}#GlobalHeader>.right>nav.menus-view>.menu-wrapper ul.menu+.menu{border-left:none;border-top:1px solid rgba(0,0,0,.3)}#GlobalHeader>.right>nav.menus-view>.menu-wrapper ul.menu li.menu-button{line-height:20px;padding-left:5px}#GlobalHeader>.right>nav.menus-view>.menu-wrapper ul.menu li.menu-button.languageswitcher{margin-bottom:6px;padding-left:1px}#GlobalHeader>.right:hover{color:#117f93}#GlobalHeader>.right:hover>nav.menus-view>.menu-wrapper{display:block}}#Messages{padding-right:10px}#Messages>.message{border-radius:4px;border-style:solid;border-width:1px;margin-bottom:4px;padding:4px 6px 4px 20px;position:relative}#Messages>.message:before{font-family:FontAwesome;left:6px;position:absolute;top:50%;transform:translateY(-50%)}#Messages>.message.-error{background-color:#ffeeed;border-color:#ff504a}#Messages>.message.-error:before{color:#ff504a;content:"ï€"}#Messages>.message.-warning{background-color:#fff7e6;border-color:#f5a700}#Messages>.message.-warning:before{color:#f5a700;content:"ï±"}#Messages>.message.-notice{background-color:#f3f9e6;border-color:#99cd32}#Messages>.message.-notice:before{color:#99cd32;content:"ïš"}#ResultsView{padding:10px 14px 14px;position:relative}#ResultsView.-not-found:after{color:#94928d;content:"Not found";display:block;font-size:14px;line-height:64px;text-align:center}#ResultsView>.header{display:flex;justify-content:space-between;position:relative;white-space:nowrap}#ResultsView>.header>.left>.heading{display:inline-block;font-size:16px;margin-bottom:-2px;margin-right:8px}#ResultsView>.header>.left>.status{display:inline-block;font-size:12px}#ResultsView>.header>.left>.status>.bigger{font-size:16px}#ResultsView>.header>.right{display:flex;gap:5px;height:16px;list-style:none;position:relative;top:4px;z-index:var(--z-index-base)}#ResultsView>.header>.right>.text{font-size:12px;font-weight:700;padding-right:3px}body[data-has-conditions] #ResultsView>.header>.right>li>.button-view{opacity:1;pointer-events:auto}#ResultsView>.header>.right>li>.button-view:active{background:var(--color-key-dark1);transform:translateY(.5px)}#ResultsView>.tablecontainer{margin-right:-14px;margin-top:-20px;overflow-x:auto;overflow-y:hidden;padding-bottom:20px}#ResultsView>.tablecontainer>.results-view>thead>tr{height:64px}#SideBar{box-shadow:inset 2px 0 3px rgba(0,0,0,.2);height:100%;overflow-y:auto;padding:15px;transform:translateX(-297px);transition:transform .2s;white-space:nowrap;width:600px}.-drawer-opened #SideBar{padding-bottom:415px}#SideBar>.sidebarcontent{display:inline-block;padding-bottom:45px;vertical-align:top;white-space:normal;width:270px}#SideBar>.sidebarcontent>.title{color:#fff;font-size:16px;font-weight:700;margin-bottom:0;position:relative;top:-5px}body[data-search-mode=advanced] #SideBar>.sidebarcontent>.title>.simple,body[data-search-mode=simple] #SideBar>.sidebarcontent>.title>.advanced{display:none}#SideBar>.sidebarcontent>.title>.button-view{float:right;font-size:12px;top:5px}body[data-search-mode=advanced] #SideBar>.sidebarcontent>.title>.button-view{display:none}#SideBar>.sidebarcontent+.sidebarcontent{margin-left:25px}body.-rowselected #SideBar{transform:translateX(0)}#SimpleSearchView{padding:14px}#SimpleSearchView>.search-field-view>.examples,#SimpleSearchView>.search-field-view>.fieldcontainer{display:none}#SimpleSearchView>.search-field-view>.fieldcontainer>.field>input[type=text]{margin-left:-3px;width:calc(100% - 27px)}#SimpleSearchView.-current>.search-field-view{padding:14px}#SimpleSearchView.-current>.search-field-view>.examples,#SimpleSearchView.-current>.search-field-view>.fieldcontainer{display:block}#SimpleSearchView.-current>.search-field-view>.suggest-view{left:23px;top:43px}._margin-bottom{margin-bottom:.5rem}._margin-left{margin-left:.5rem}._padding-right-large{padding-right:2rem}._align-left{text-align:left}._align-center{text-align:center}._align-right{text-align:right}._flex{display:flex}._break-avoid{break-inside:avoid}._width_5em{width:5em}._column-span-all{column-span:all}._nowrap{overflow-x:hidden;white-space:nowrap} /*# sourceMappingURL=main-8277e96c5d1694737ec5.css.map*/